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Clin Colon Rectal Surg 2025; 38(03): 229-236
DOI: 10.1055/s-0044-1787826
DOI: 10.1055/s-0044-1787826
Review Article
Systemic Therapy for Metastatic Colon Cancer: New Frontiers
Authors
Funding The author declares stock ownership in Pfizer, honoraria from Janssen, and participation on the advisory board of BMS.
Abstract
We have made steady gains in improving overall survival in patients with metastatic, unresectable, colon cancer in the last 5 to 10 years. The backbone of systemic treatment for most patients remains combination chemotherapy, but the field is becoming increasingly biomarker driven, with exciting new targeted therapies on the horizon. This review is organized in sections corresponding to currently relevant biomarkers in colon cancer and will summarize first-, second-, and third-line standard of care for metastatic, unresectable, colon cancer. The last section is intended to introduce the reader to promising agents and novel therapeutic strategies currently under investigation.
Publication History
Article published online:
25 June 2024
© 2024. Thieme. All rights reserved.
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